Detalhe da pesquisa
1.
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
PLoS Pathog
; 18(10): e1010926, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36306287
2.
Role of MUC5B during Group B Streptococcal Vaginal Colonization.
mBio
; 13(2): e0003922, 2022 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35323039
4.
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Elife
; 102021 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34279219
5.
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
J Med Chem
; 64(9): 6085-6136, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33876936
6.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Sci Transl Med
; 13(603)2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290058
7.
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis
; 5(1): 90-101, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30375858
8.
Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study.
Lancet Infect Dis
; 18(8): 874-883, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29909069